Identification of the sialic acid structures recognized by minute virus of mice and the role of binding affinity in virulence adaptation*

HIGHLIGHTS

• who: Hyun-Joo Nam from the MVMp and the virulent MVMp mutants were compared (11)Significantly, as with the in vitro assays, the double mutant MVMp-I S/K R showed the lowest affinity for the glycans tested (Fig., ). As discussed above, residues , and , are found along the wall of the, fold depression, close to the sialic acid binding site (Fig., ) (11). Thus, it is likely that disrupted glycan interactions with these residues play a role in their reduced affinity compared with the MVMi and MVMp (Figs. , , ). These observations provide further support that the virulent adaptation by . . .
  

   

  

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