Identification of the toxic 6mer seed consensus for human cancer cells

HIGHLIGHTS

• who: Monal Patel from the DepartmentUniversity, Chicago, IL, have published the research: Identification of the toxic 6mer seed consensus for human cancer cells, in the Journal: Scientific Reports Scientific Reports of 12/07/2021
• what: The genes downregulated in the siGGG​GGC​transfected cells 48 h after transfection were enriched in a reference set of recently defined survival ­genes10 (Fig 3A), similar to the activity the authors reported for the two tumor suppressive miRNAs miR-34a-5p and miR-15/16-3p and their matching 6mer seed containing s­ iRNAs13,15. Because the toxic seeds . . .
  

   

  

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