Identifying novel mechanisms of abdominal aortic aneurysm via unbiased proteomics and systems biology

HIGHLIGHTS

  • who: Masanori Aikawa from the Kurume University, Japan have published the research: Identifying novel mechanisms of abdominal aortic aneurysm via unbiased proteomics and systems biology, in the Journal: (JOURNAL)
  • what: The aim of this study involved identifying and comparing proteins and molecular pathways defining the two most commonly used mouse AAA models: AngII infusion into Apoe-/- or Ldlr-/- male mice, and the localized, luminal perfusion with elastase into the infrarenal aorta of male wildtype mice . The study design includes the consideration of temporal features for each group aiming to capture developing and late-stage aneurysmal . . .

     

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