Ifnγ signaling in cytotoxic t cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like t cells

HIGHLIGHTS

• who: Julie M. Mazet from the Mice Mice were bred and maintained in the University of Oxford specific pathogen-free (SPF) animal facilitiesMice were routinely screened for the absence of pathogens and were kept in individually ventilated cages with environmental enrichment at, u00b0C, % humidity with a , h light/dark cycle (7am-7pm) with half an hour dawn and dusk period. CD8u03b1-Cre mice (The Jackson Laboratory, ) were crossed with Rosa-floxSTOPflox-Tomato (The Jackson Laboratory, ) and flox-IFNu03b3R1-flox (The Jackson Laboratory, ) to specifically deplete IFNu03b3, in mature , + T cells. IFNu03b3R-/- (The Jackson Laboratory, ) were crossed with . . .
  

   

  

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