Igate analysis improves the interpretability of single-cell immune landscape of influenza infection

HIGHLIGHTS

• What: Applying iGATE to study effects of host genetic background the authors show that the lower survival of C57BL/6 mice compared with BALB/c was associated with a more rapid accumulation of inflammatory cell types and decreased IL-10 expression. The authors demonstrate that the most prominent effect of aging is a defective T cell response reducing survival of aged mice. The authors apply cytometry by time-of-flight (CyTOF) to comprehensively investigate how host genetic background (C57BL/6 vs. BALB/c) and aging (2 vs. 18 months) affect the immune_response to influenza infection in the . . .
  

   

  

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