HIGHLIGHTS
- who: Louisa Hill from the (UNIVERSITY) have published the research: Igh and Igk loci use different folding principles for V gene recombination due to distinct chromosomal architectures of pro-B and pre-B cells, in the Journal: (JOURNAL) of 26/08/2022
- what: Based on these data, the authors propose that the contraction of the Igk locus by many internal loops promotes diffusion-mediated alignment of the RSS sequences of distal VK genes and proximal JK elements to facilitate RAG-mediated cleavage and recombination (Fig 7). Instead, the authors show here by highresolution Micro-C . . .
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