HIGHLIGHTS
- who: Yamei Jiang from the Brown University, United States have published the paper: IL-10 partly mediates the ability of MSC-derived extracellular vesicles to attenuate myocardial damage in experimental metabolic renovascular hypertension, in the Journal: (JOURNAL)
- what: The study shows that WT-EVs promoted macrophage polarization from an inflammatory M1 to a reparative M2 phenotype, increased the infiltration of reparative Tregs in_vivo, and decreased the expression of inflammatory cytokines in myocardial tissue, exhibiting their immunoregulatory ability. This study shows that IL-10 content modulates the ability of MSC-derived EVs to improve impaired cardiac . . .
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