HIGHLIGHTS
SUMMARY
Keyword CD8+ T_cell, bystander activation, IL-15, NKG2D, HTNV, hemorrhagic fever with renal syndrome, endothelial cell the pathological responses of activated CD8+ T_cells during HTNV infection (Tariq and Kim, 2022). The pre-existing memory CD8+ T_cells that are non-specific to the infectious pathogens could be activated in a cytokinedependent manner without T_cell receptor (TCR) stimulation, which may mediate host injury during the early stages of viral infections (Lee et_al, 2022). Studies have revealed that IL-15 could induce the expression of NKG2D on CD8+ T_cells in a strong dose-dependent manner in the . . .
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