Il-39 promotes chronic graft-versus-host disease by increasing t and b cell pathogenicity

HIGHLIGHTS

• who: Kangkang Lv from the of, Affiliated Hospital of Soochow University, Shizi Street, Suzhou, China have published the paper: IL-39 promotes chronic graft-versus-host disease by increasing T and B Cell pathogenicity, in the Journal: (JOURNAL)
• what: The authors demonstrated that overexpression of IL-39 aggravated cGVHD, whereas blocking of IL-39 attenuated immune dysregulation in the cGVHD mice. The authors provide direct evidence for IL-39 pathogenic role in aggravating cGVHD by activating T and B cells and promoting pro-inflammatory cytokine secretion.
• how: The data indicated that overexpression of . . .
  

   

  

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