HIGHLIGHTS
- who: Durga Sivanesan from the (UNIVERSITY) have published the research: IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking*, in the Journal: (JOURNAL) of April/15,/2016
- what: The authors provide clear mechanistic details of loss of activity for the three protective variants, all of which result in reduced cell surface expression of mature recepVOLUME 291. The observations that the IL23R appears to be activated in a similar manner to erythropoietin receptor provides a mechanistic target for therapeutic development, and the . . .
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