Immune cells and their related genes provide a new perspective on the common pathogenesis of ankylosing spondylitis and inflammatory bowel diseases

HIGHLIGHTS

SUMMARY

    Innate cells, including mast cells, neutrophils and macrophages, as well as innate lymphoid cells and innate-like T_cells were reported to be involved in the pathogenesis of AS. A meta analysis showed that the proportions of CD4+ T_cells, Th17 cells, Tfh cells as well as Th1/Th2 ratio were significantly increased and Tregs were significantly decreased among the subsets of T_cells, while the percentages of T_cells were not significantly different. One possible explanation is that there are many subsets of CD4+ T_cells and CD8+ T_cells, while some of them have increased and others have . . .

     

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