Immune checkpoint proteins, metabolism and adhesion molecules: overlooked determinants of car t-cell migration?

HIGHLIGHTS

  • who: Luca Simula et al. from the Normandie Universitu00e9, Caen, France have published the Article: Immune Checkpoint Proteins, Metabolism and Adhesion Molecules: Overlooked Determinants of CAR T-Cell Migration?, in the Journal: Cells 2022, 11, 1854. of /2022/
  • what: The aim of this review is to focus on other and overlooked determinants that are susceptible to restrain the trafficking of CAR T_cells in solid tumors and therefore prevent them from forming conjugates with their targets. Over the last years, studies were conducted to compare the behavior of T_cells contacting tumor cells through the TCR or . . .

     

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