HIGHLIGHTS
SUMMARY
Breast cancer (BC) is the leading cause of cancer death among women. Meanwhile, cytotoxic T_cells and helper T_cells are required for pyroptosis-induced tumor regression. Functional follicular helper T_cells (Tfh) oriented by T-helper 1 (Th1) cells can promote humoral and cytotoxic immune_responses in human breast cancer, and the presence of CXCL13-producing Tfh cells in tertiary lymphoid structures (TLS) of breast tumors robustly predicts positive clinical outcomes. Gamma delta T_cells target tumor cells in TNBC, and their numbers in TME are positively related to the immunotherapy response of patients with advanced BC. Activated . . .
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