HIGHLIGHTS
- who: Alice Clare Newman from the Institut University of Glasgow, Switchback Road, Glasgow , QH, UK have published the paper: Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells, in the Journal: (JOURNAL)
- what: Using vitro and vivo pancreatic cancer models the authors show that IDO1 expression is highly context dependent influenced by attachment-independent growth and the canonical activator IFNg. The authors show that cancer cells release tryptophan-derived formate which can be used by pancreatic stellate cells to support purine nucleotide synthesis. Analysis of public . . .
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