HIGHLIGHTS
SUMMARY
MPS treatment is thought to target T_cells almost exclusively by induction of apoptosis and exert only a minor effect on soluble factors. Among CD4 + T_cells, a relevant reduction of CD4 + memory T_cells (176/µL vs. 238/µL at baseline; p=0.025) as well Th1 cells (1.6/µL vs. 6.5/µL; p=0.003) and follicular T helper cells (3.5/µL vs. 8.1/µL; p=0.007) following MPS treatment was observed, whereas IA had no effect. Interestingly, MPS patients showed ongoing suppression of recent-thymic emigrant regulatory T_cells (0 . . .
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