HIGHLIGHTS
- who: Aalia N. Khan from the Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai, India Tarbiat Modares University, Iran have published the research: Immunogenicity of CAR-T Cell Therapeutics: Evidence, Mechanism and Mitigation, in the Journal: (JOURNAL)
- what: Findings of this study provide the foundation for designing CARs with lower immunogenicity by using only human heavy chain domains rather than murine sequences .
- how: A non-signaling CAR (11D5-3-NS) was generated in this work with sequences that were identical to the CAR-BCMA that had previously been evaluated in . . .
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