Immunoglobulin superfamily containing leucine-rich repeat (islr) serves as a redox sensor that modulates antioxidant capacity by suppressing pyruvate kinase isozyme m2 activity

HIGHLIGHTS

• What: The authors provide the first evidence that, upon oxidative stress, ISLR serves as an ROS sensor that perceives the change in ROS levels through Cys19 in its N-terminal LRRNT domain; then, it rapidly degraded in the autophagy-lysosomal pathway. The authors propose that intracellular pyruvate can function as a critical antioxidant, and the enhanced antioxidant capacity of PKM2 activation can be achieved by enhancing pyruvate production. According to these findings, the authors propose that ISLR is involved in the enhancement of the cellular antioxidant capacity when cancer cells are treated with cisplatin, and, as expected . . .
  

   

  

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