Immunometabolic factors contributing to obesity-linked hepatocellular carcinoma

HIGHLIGHTS

• who: TYPE and colleagues from the Fudan University, China have published the research: Immunometabolic factors contributing to obesity-linked hepatocellular carcinoma, in the Journal: (JOURNAL) of 03/Nov/2022
• what: The authors focus on the role of hepatic oxidative stress, which is a common feature of most NASH-linked metabolic insults, and the role of hepatic cholesterol excess, which has emerged to be a potential key turning point in triggering chronic liver inflammation. Using mice, this study showed CD4+ T_cell loss resulted from increased mitochondrial ROS generated via fatty_acid oxidation, and that blockage of ROS . . .
  

   

  

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