Immunomodulation by glucocorticoid-induced leucine zipper in macrophages: enhanced phagocytosis, protection from pyroptosis, and altered mitochondrial function

HIGHLIGHTS

• What: The study demonstrates enhanced phagocytic activity and increased killing efficacy of S. typhimurium and E. coli by GILZoverexpressing macrophages, potentially mediated by an increased capacity to produce nitric oxide (NO). In this context, Frontiers in Immunology Considering the discovery that GILZ overexpression protects macrophages from pyroptosis, the authors propose a potential regulatory role for GILZ in the pyroptotic cell death pathway.
• Who: . et al. from the Indian Institute of Technology Palakkad, India University of California, San Diego have published the paper: Immunomodulation by glucocorticoid-induced leucine zipper in macrophages: enhanced phagocytosis, protection from pyroptosis . . .
  

   

  

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