Immunomodulatory effects of new phytotherapy on human macrophages and tlr4- and tlr7/8-mediated viral-like inflammation in mice

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SUMMARY

Typically, TLR-mediated immune_response involves an increase in circulating and central cytokines such as IL-1β, TNF and IL6, as well as chemokines such as CXCL1, CCL2 and CXCL10 and the induction of "sickness behavior," i.e., reduced activity and exploration, and anxiety-like changes. The authors investigated the effects of a new immunomodulatory phytotherapy (IP), an extract of blackberry, chamomile, garlic, cloves, and elderberry (for the IP content, see Supplementary Table 1), that was designed as an anti-inflammatory composition (see Supplementary File) in previously established in_vitro and in_vivo models of inflammation. The . . .

 



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