HIGHLIGHTS
- who: Rupert L. Mayer from the (UNIVERSITY) have published the research work: Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes, in the Journal: (JOURNAL) of 15/07/2022
- how: The authors used Listeria monocytogenes as a clinically relevant bacterial model pathogen to infect HeLa and HCT116 cells two human epithelial_cell lines and the authors identified Listeria immunopeptides presented on MHC class I molecules by a hybrid MS approach combining label-free and TMT-labeled measurements.
SUMMARY
Encoding these highly presented antigens in lipid nanopArticle mRNA_vaccine formulations results in specific . . .
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