Immunopeptidomics of colorectal cancer organoids reveals a sparse hla class i neoantigen landscape and no increase in neoantigens with interferon or mek-inhibitor treatment

HIGHLIGHTS

• who: Alice Newey from the Institute of Cancer Research, Fulham Road, London , JB, UK have published the paper: Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment, in the Journal: (JOURNAL)
• what: The authors show this enables large-scale expansion of PDOs to several hundred million cells, sufficient for in-depth immunopeptidomic analyses. The study shows that MS-based immunopeptidomics is feasible from CRC PDOs.
• how: The authors identified an average of 9936 unique peptides per PDO which . . .
  

   

  

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