Immunoproteasome and non-covalent inhibition: exploration by advanced molecular dynamics and docking methods

HIGHLIGHTS

• who: Giulia Culletta and collaborators from the (UNIVERSITY) have published the paper: Immunoproteasome and Non-Covalent Inhibition: Exploration by Advanced Molecular Dynamics and Docking Methods, in the Journal: Molecules 2021, 4046 of 20/05/2021
• what: For this study, the authors selected the catalytic subunit β1i (LMP2 and PSMB9) extracted from the murine i20S in complex with the inhibitor ONX-0914 bound to the β5i subunit (PDB ID: 3UNF) . The authors investigated the mechanism of non-covalent inhibition of the potent and selective immunoproteasome inhibitor 1.
• how: The authors employed employed advanced molecular . . .
  

   

  

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