HIGHLIGHTS
- who: Marta del Rio Oliva and collaborators from the University of Gdansk, Poland have published the research: Immunoproteasome inhibition attenuates experimental psoriasis, in the Journal: (JOURNAL)
- what: In this study, the therapeutic potential of immunoproteasome inhibition in psoriasis pathogenesis was assessed in Card14mediated and IMQ-induced psoriasiform models. Taken together, this study shows that ONX 0914 significantly reduced the skin thickness and pathological features in two different murine model of psoriasis. Even though most of the studies have focused on ab+ T_cells, there is increasing evidence that aberrantly activated gd+ T_cells play an important role . . .
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