HIGHLIGHTS
SUMMARY
Several metaanalyses reported no beneficial effect of vitamin C on the risk of mortality in cardiac surgical patients and those with COVID-19 infection. Such conflicting findings may be attributed to the variations among individual studies including study design (i.e., prospective or retrospective), the choice of study population (e_g, critical vs. non-critical), the use of vitamin C as monotherapy or part of a combined regimen, as well as the selected dosage and route of administration. In contrast, a recent large-scale randomized controlled trial (RCTs) involving 872 patients with sepsis even reported . . .
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