Impact of the dual deletion of the mitochondrial sirtuins sirt3 and sirt5 on anti-microbial host defenses

HIGHLIGHTS

• who: Thierry Roger from the Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Epalinges, Switzerland have published the Article: Impact of the Dual Deletion of the Mitochondrial Sirtuins SIRT3 and SIRT5 on Anti-microbial Host Defenses, in the Journal: (JOURNAL)
• what: Together with the fact that SIRT3-/- and SIRT5-/- mice are susceptible to bacterial sepsis like wild-type mice , these observations strengthen the development of pharmacological modulators of the activity of mitochondrial sirtuins for clinical purposes.
• how: Considering that inflammation is an essential component of innate immune defenses . . .
  

   

  

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