Impacts of mutations in the p-loop on conformational alterations of kras investigated with gaussian accelerated molecular dynamics simulations

HIGHLIGHTS

• who: Shuhua Shi and collaborators from the School of Science, Shandong Jianzhu University, Jinan, China have published the Article: Impacts of Mutations in the P-Loop on Conformational Alterations of KRAS Investigated with Gaussian Accelerated Molecular Dynamics Simulations, in the Journal: Molecules 2023, 28, x FOR PEER REVIEW of /2023/
• what: These two facts are the main reason why the authors selected the RMSDs and the distance as RCs.

SUMMARY

Despite these successes, molecular mechanism of mutation-induced duced conformational state changes of the switch domains from KRAS are still insufficient . . .

 



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