Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney

HIGHLIGHTS

• who: Beatrice Paola Festa from the Institute University of have published the research work: Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS

SUMMARY

Despite the identification of cellular defects associated with cystinosis in different models and cell systems10, a unifying mechanism linking loss of cystinosin, lysosomal dysfunction, and defective epithelial transport has not been deciphered. In most mammalian cells, the endolysosomal system captures and degrades intracellular worn-out constituents through autophagy11. Of note, accumulation of distorted mitochondria15 and of autophagy receptor SQSTM1 . . .

 



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