HIGHLIGHTS
- who: Xiaojing Mao and collaborators from the Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA have published the research work: Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome, in the Journal: (JOURNAL) of 11/05/2022
- what: The authors investigated the early development of keratinocytes in HGPS.
SUMMARY
Hutchinson-Gilford Progeria syndrome (or HGPS, progeria) is an ultra-rare but devastating genetic disorder that causes premature aging in children. The accumulation of progerin in the cell nucleus induces abnormal nuclear . . .
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