HIGHLIGHTS
- who: Sicheng Fu from the Affiliated Hospital University of have published the Article: Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors report an important role of lipid synthesis, especially cholesterol synthesis, in promoting activation, proliferation, and effector function of iNKT_cells. Together, the authors demonstrate that impaired lipid synthesis hinders anti-tumor effect of tumor-infiltrating iNKT_cells.
- how: These results indicated that PPARγ-controlled lipid synthesis promoted IFN-γ production in iNKT_cells at the transcriptional level. In the studies when iNKT_cells were . . .
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