Impaired proteolysis of collagen i inhibits proliferation of hepatic stellate cells

HIGHLIGHTS

• who: Xiaoying Zhou from the Xiaoying Zhou1, Aqeel Jamil2, Andrew Nash3, James Chan, Nathan Trim, John PIredale4, , and R. Christopher Benyon4, , From the Liver Group, University Division of Infection, Inflammation and Repair, Southampton General Hospital, Southampton, Hants, YD, United Kingdom Myofibroblastic-activated hepatic stellate cells are the major source of the collagen, rich extracellular matrix in liver fibrosis but also produce matrix metalloproteinases, which remodel this protein. We have investigated the role of collagen I proteolysis in both regulating proliferation and maintaining the activated myofibroblastic phenotype of stellate cells in vitro. Compared with stellate cells plated on . . .
  

   

  

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