HIGHLIGHTS
- What: Mechanistically, the authors demonstrate that the perturbation of this traffic, leads to a compensatory lysosome neo-biogenesis devoided of degradative enzymes. The work proposes a strategy to take benefits of melanoma physiological reaction to lysosomal stress to prevent melanoma invasion.
- Who: Alice Nordlinger from the (UNIVERSITY) have published the paper: Impairing hydrolase transport machinery prevents human melanoma metastasis, in the Journal: (JOURNAL)
- How: The data indicated that although the addition of active TGFβ induced its signaling as seen by the induction of SMAD2 phosphorylation (Supplementary Fig 1a) this cytokine could not rescue . . .
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