Impairing proliferation of glioblastoma multiforme with cd44+ selective conjugated polymer nanoparticles

HIGHLIGHTS

  • who: Dorota Lubanska from the DepartmentUniversity of USA have published the Article: Impairing proliferation of glioblastoma multiforme with CD44+u2009selective conjugated polymer nanoparticles, in the Journal: Scientific Reports Scientific Reports
  • what: Using single spheres generated from primary patient cells embedded in Matrigelu2122, supplemented with either vehicle control or 24 HA-CPNs/cell the authors demonstrate that presence of HA-CPNs in the Matrigel significantly decreased the distance of invasion compared to the vehicle control. A careful, multi-assay evaluation provided in this study shows that DPP-CPNs, generated with HA, can selectively target CD44 + cells . . .

     

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