HIGHLIGHTS
SUMMARY
Chronic pancreatitis (CP) is a multifactorial inflammatory disease in which recurrent episodes of inflammation lead to irreversible pancreatic tissue damage and consequently loss of function. The COMBO trial aims to assess to what extent patient education and a structured implementation of an evidence-based algorithm including multiple interventions improve clinical outcomes in patients with CP. The COMBO trial is the first stepped-wedge cluster-randomized controlled trial designed to determine whether standardization of care through the implementation of an evidence-based algorithm improves clinical outcomes in patients with CP. Although several interventions have been . . .
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