Implications of gclc in prognosis and immunity of lung adenocarcinoma and multi-omics regulation mechanisms

HIGHLIGHTS

• What: Together the authors show that GCLC and relevant genes exert crucial roles in LUAD prognosis and immunity and their expression can be controlled by complex multi-omics mechanisms. This work determined aberrantly expressed miRNAs (hsa-mir-30c-1, hsamir-328, hsa-mir-1301, hsa-mir-326, and hsa-mir-193b) as well as lncRNAs (C8orf34-AS1, FENDRR, FMR1-AS1, HELLPAR, and NRAV) that possibly contributed to the aberrant expression of GCLC and relevant prognostic genes in LUAD via the post-transcriptional modulation mechanisms. This work shows the clinical implications of GCLC and relevant genes for prognosis . . .
  

   

  

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