Imprecise medicine: brca2 variants of uncertain significance (vus), the challenges and benefits to integrate a functional assay workflow with clinical decision rules

HIGHLIGHTS

  • who: Judit Jimenez-Sainz and Ryan B. Jensen from the Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA have published the research: Imprecise Medicine: BRCA2 Variants of Uncertain Significance (VUS), the Challenges and Benefits to Integrate a Functional Assay Workflow with Clinical Decision Rules, in the Journal: Genes 2021, 12, x FOR PEER REVIEWcontaining of 25/04/2021
  • what: In this review the authors provide brief overview of BRCA2 functions in HDR describe how BRCA2 VUS are currently assessed in the clinic and how genetic and biochemical assays could be . . .

     

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