Improved prediction of early cognitive impairment in multiple sclerosis combining blood and imaging biomarkers

HIGHLIGHTS

• who: Tobias Brummer et al. from the In total, multiple sclerosis patients underwent MRI scans (details listed in the following context) and sNfL measurement at the outpatient clinic of the Department of Neurology, at the University Medical Center in Mainz (Germany) (Table, )Of the , patients included, had clinically isolated syndrome (CIS) with no dissemination in time, whereas the remaining , had relapsing-remitting multiple sclerosis (RRMS) as diagnosed according to the , revised McDonald diagnostic criteria [28]. The mean disease duration of all patients at time point of the first sNfL measurement (study entry) was, ., +, ., years. Neuropsychological assessment (see . . .
  

   

  

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