Improving aqueous solubility and in vitro pharmacokinetic properties of the 3-nitroimidazo[1,2-a]pyridine antileishmanial pharmacophore

HIGHLIGHTS

  • who: Romain Paoli-Lombardo and colleagues from the CNRS, ICR, Team Pharmaco-Chimie Radicalaire, Facultu00e9 de Pharmacie, Aix Marseille University, Boulevard Jean Moulin, CS30064, , Marseille, France have published the paper: Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2-a]pyridine Antileishmanial Pharmacophore, in the Journal: Pharmaceuticals 2022, 998 of /2022/
  • what: This antileishmanial SAR study, which focused on positions 2 and 8 of the imidazo[1,2a]pyridine ring, was conducted through the synthesis and assessment of 22 new derivatives.

SUMMARY

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