Improving nelarabine efficacy in t cell acute lymphoblastic leukemia by targeting aberrant pi3k/akt/mtor signaling pathway

HIGHLIGHTS

  • who: Annalisa Lonetti from the Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy have published the Article: Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway, in the Journal: (JOURNAL)
  • what: In this context a major contribution was provided by the introduction of the nucleoside analog nelarabine approved for salvage treatment of T-ALL patients with refractory/relapsed disease.

SUMMARY

    To better understand the role of Bcl2 family, it was first investigated the gene_expression of Bcl2 and Bcl-xL genes . . .

     

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