HIGHLIGHTS
- who: Martina McMenamin from the (UNIVERSITY) have published the research: Improving the analysis of composite endpoints in rare disease trials, in the Journal: (JOURNAL)
- what: The authors investigate small sample properties and implement small sample corrections. The authors implement Firth's adjustment for the binary component models and a small sample variance correction for the generalized estimating equations applying the small sample adjusted methods to each sub-sample as before for comparison. The authors have explored the small sample properties of the standard binary and augmented binary methods and proposed adjustments to improve them.
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