HIGHLIGHTS
- who: Therapeutic Gene Delivery and collaborators from the University School of Medicine have published the article: Improving the eufffdciency of liver targeting rAAV- mediated homologous recombination using ribonucleotide reductase inhibitors, in the Journal: (JOURNAL)
- what: The authors determined RNR inhibitors are useful drugs to enhance AAV-HR efficiency. Since the precise mechanism of rAAV-mediated gene targeting is not fully understood, particularly in_vivo, unveiling the details of such mechanisms will be the focus of the future studies.
- how: To validate RNR inhibition as the mechanism for increased gene targeting the authors used siRNA . . .
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