In-depth characterization of endo-lysosomal a in intact neurons

HIGHLIGHTS

• who: Alec K. McKendell and colleagues from the Massachusetts General Hospital, Harvard Medical School, , th street, Charlestown, MA, USA Department of Medicinal Chemistry, University of Kansas, Irving Hill Rd, Lawrence have published the paper: In-Depth Characterization of Endo-Lysosomal A in Intact Neurons, in the Journal: Biosensors 2022, 12, 663. of 20/08/2022
• what: The authors report using fluorescent lifetime imaging microscopy (FLIM) that intracellular Aβ includes both long Aβ intermediates bound to γ-secretase and short peptides dissociated from the protease complex. The authors show striking cell-to-cell heterogeneity in intracellular A . . .
  

   

  

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