In silico analyses indicate a lower potency for dimerization of tlr4/md-2 as the reason for the lower pathogenicity of omicron compared to wild-type virus and earlier sars-cov-2 variants

HIGHLIGHTS

• What: The in silico analyses presented in this study have shown that, despite a comparable binding activity, the Omicron spike_protein shows a lower potency for dimerization of human TLR4/MD-2, due to amino_acid substitutions and slight conformational shifts in the FP/HR1 region of the S2 subunit .
• Who: Ralf Kircheis from the (UNIVERSITY) have published the paper: In Silico Analyses Indicate a Lower Potency for Dimerization of TLR4/MD-2 as the Reason for the Lower Pathogenicity of Omicron Compared to Wild-Type Virus and Earlier SARS-CoV-2 Variants, in the Journal: (JOURNAL . . .
  

   

  

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