In silico analysis of tuba4a mutations in amyotrophic lateral sclerosis to define mechanisms of microtubule disintegration

HIGHLIGHTS

• who: Akshatha Ganne from the DepartmentUniversity of have published the Article: In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration, in the Journal: Scientific Reports Scientific Reports
• what: This study provides structural insights into the mechanisms whereby single-amino-acid substitutions in the TUBA4A sequence can exert broad impacts on GTP binding, dimer stability, and susceptibility to aggregation. The authors focused on the impact of reported mutations on GTP-dependent tubulin polymerization.

SUMMARY

To determine the structural impact of each TUBA4A mutation associated with . . .

 



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