In silico genome-scale metabolic modeling and static time-kill studies of exogenous metabolites alone and with polymyxin b against klebsiella pneumoniae

HIGHLIGHTS

• who: . and collaborators from the Zunyi Medical, China have published the research: In silico genome-scale metabolic modeling and static time-kill studies of exogenous metabolites alone and with polymyxin B against Klebsiella pneumoniae, in the Journal: (JOURNAL)
• what: The aim of this study was to identify promising polymyxin B-metabolite combinations against MDR K. pneumoniae using GSMM coupled with time-kill studies. The emergence of polymyxin resistance in K. pneumoniae clinical isolates through diverse genetic adaptation has renewed the research focus on the importance of combination therapy. Pharmacodynamic analysis was carried out to determine . . .
  

   

  

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