In silico mutational analysis to identify the role and pathogenicity of bcl-w missense variants

HIGHLIGHTS

  • who: Poonam Kumari from the (UNIVERSITY) have published the Article: In silico mutational analysis to identify the role and pathogenicity of BCL-w missense variants, in the Journal: (JOURNAL)
  • what: Proteins are dynamic in nature as they are flexible in nature due to temperature, pH, and interaction with other molecule may be a ligand.

SUMMARY

    The pro-survival proteins possess BH1-4 domains e_g BCL-2, BCL-XL, MCL1, BCL-w, and A1/BFL-1. Multi-domain pro-apoptotic proteins contains BH1-3 domains, e_g, BAX and BAK, and lastly the . . .

     

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