In situ expansion and reprogramming of kupffer cells elicit potent tumoricidal immunity against liver metastasis

HIGHLIGHTS

• who: Wei Liu and collaborators from the Departmentthe University, Hefei, Anhui, China have published the research: In situ expansion and reprogramming of Kupffer cells elicit potent tumoricidal immunity against liver metastasis, in the Journal: (JOURNAL)
• what: Taking advantage of the superior capacity of KCs to capture circulating bacteria the authors report that a single administration of attenuated Escherichia coli producing clustered regularly interspersed short palindromic repeats Casu03a6 (CRISPR/Casu03a6) machinery enables efficient editing of genes of interest in KCs. The authors report a simple and economical strategy for genetically modifying and functionally reprogramming KCs in_vivo . . .
  

   

  

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