In vitro and in silico investigations of natural compounds with predicted activity against neuroblastomas “2279

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SUMMARY

    Glioblastoma is one of the most common and aggressive types of malignant brain tumors affecting the central nervous system in adults; current therapeutic approaches usually involve surgical intervention, chemo, and radiotherapy, but its invasive nature and high resistance to conventional therapies raise major health concerns. To prove this, some recent in_vitro studies using a transepithelial anti-neuroblastoma co-culture model system, in which several diluted juices from plants (kale, dandelion, lettuce, and spinach) 2 of 6 were applied to apical Caco-2Bbe1 cells atop dividing SH-SY5Y neuroblastoma cells, indicated inhibitory activity for kale . . .

     

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