In vitro genome editing activity of cas9 in somatic cells after random and transposon-based genomic cas9 integration

HIGHLIGHTS

• who: Jenny-Helena Su00f6llner et al. from the Mecklenburg-Western Pomerania, Germany have published the paper: In vitro genome editing activity of Cas9 in somatic cells after random and transposon-based genomic Cas9 integration, in the Journal: PLOS ONE of 29/Nov/2022
• what: We generated functional Cas9 expressing pigs which remained fertile and healthy and therefore are suitable for establishing a Cas9 breeding line.
• future: A more detailed investigation of off-target mutations in Cas9 expressing pigs would be necessary when developing human disease models.

SUMMARY

Thereby, germline . . .

 



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