In vitro metabolic zonation through oxygen gradient on a chip

HIGHLIGHTS

  • who: Federica Tonon from the Deptof Life Sciences, University of Trieste, Trieste, Italy. Stem Cell and Regenerative Medicine Section have published the paper: In vitro metabolic zonation through oxygen gradient on a chip, in the Journal: Scientific Reports Scientific Reports of 28/09/2018
  • what: The aim of this study is to understand whether an oxygen gradient generated in vitro in the developed device is sufficient to instruct a functional metabolic zonation during the differentiation of human embryonic stem cells (hESCs) from endoderm toward terminally differentiated hepatocytes thus mimicking the in vivo situation. In this . . .

     

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